Major Determinants of Airway Epithelial Cell Sensitivity to S. aureus Alpha-Toxin: Disposal of Toxin Heptamers by Extracellular Vesicle Formation and Lysosomal Degradation

Alpha-toxin is a major virulence factor of Staphylococcus aureus. Monomer binding to host cell membranes results in the formation of heptameric transmembrane pores. Among human model airway epithelial cell lines, A549 cells were most sensitive toward the toxin followed by 16HBE14o(-) and S9 cells. I...

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Detalles Bibliográficos
Autores principales: Möller, Nils, Ziesemer, Sabine, Hentschker, Christian, Völker, Uwe, Hildebrandt, Jan-Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7996177/
https://www.ncbi.nlm.nih.gov/pubmed/33668237
http://dx.doi.org/10.3390/toxins13030173

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7996177/
https://www.ncbi.nlm.nih.gov/pubmed/33668237
http://dx.doi.org/10.3390/toxins13030173

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