Design, Synthesis, and Biological Evaluation of a Series of 5- and 7-Hydroxycoumarin Derivatives as 5-HT(1A) Serotonin Receptor Antagonists

We have designed and synthesized a series of 60 new 5- and 7-hydroxycoumarin derivatives bearing the piperazine moiety with the expected binding to 5-HT(1A) and 5-HT(2A) receptors. Molecular docking of all investigated compounds revealed subnanomolar estimates of 5-HT(1A)R K(i) for three ligands and...

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Detalles Bibliográficos
Autores principales: Ostrowska, Kinga, Leśniak, Anna, Czarnocka, Zuzanna, Chmiel, Jagoda, Bujalska-Zadrożny, Magdalena, Trzaskowski, Bartosz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7996328/
https://www.ncbi.nlm.nih.gov/pubmed/33668396
http://dx.doi.org/10.3390/ph14030179

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7996328/
https://www.ncbi.nlm.nih.gov/pubmed/33668396
http://dx.doi.org/10.3390/ph14030179

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