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Rescue of Infectious Rotavirus Reassortants by a Reverse Genetics System Is Restricted by the Receptor-Binding Region of VP4

The rotavirus species A (RVA) capsid contains the spike protein VP4, which interacts with VP6 and VP7 and is involved in cellular receptor binding. The capsid encloses the genome consisting of eleven dsRNA segments. Reassortment events can result in novel strains with changed properties. Using a pla...

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Detalles Bibliográficos
Autores principales: Falkenhagen, Alexander, Huyzers, Marno, van Dijk, Alberdina A., Johne, Reimar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7996497/
https://www.ncbi.nlm.nih.gov/pubmed/33668972
http://dx.doi.org/10.3390/v13030363