K-Ras Peptide Mimotope Induces Antigen Specific Th1 and B-Cell Immune Responses against G12A-Mutated K-Ras Antigen in Balb/c Mice

KRAS G12A somatic point mutation in adenocarcinomas is categorized clinically as ineligibility criteria for anti-epidermal growth factor receptor (EGFR) monoclonal antibody therapies. In this study, a modified G12A-K-ras epitope (139A) with sequence-specific modifications to improve immunogenicity w...

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Detalles Bibliográficos
Autores principales: Siak, Pui Yan, Wong, Kuan Yee, Song, Adelene Ai-Lian, Rahim, Raha Abdul, In, Lionel Lian Aun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7996567/
https://www.ncbi.nlm.nih.gov/pubmed/33652552
http://dx.doi.org/10.3390/vaccines9030195

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7996567/
https://www.ncbi.nlm.nih.gov/pubmed/33652552
http://dx.doi.org/10.3390/vaccines9030195

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