Cargando…

Nrf2 Signaling Pathway in Chemoprotection and Doxorubicin Resistance: Potential Application in Drug Discovery

Doxorubicin (DOX) is extensively applied in cancer therapy due to its efficacy in suppressing cancer progression and inducing apoptosis. After its discovery, this chemotherapeutic agent has been frequently used for cancer therapy, leading to chemoresistance. Due to dose-dependent toxicity, high conc...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mirzaei, Sepideh, Zarrabi, Ali, Hashemi, Farid, Zabolian, Amirhossein, Saleki, Hossein, Azami, Negar, Hamzehlou, Soodeh, Farahani, Mahdi Vasheghani, Hushmandi, Kiavash, Ashrafizadeh, Milad, Khan, Haroon, Kumar, Alan Prem
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7996755/ https://www.ncbi.nlm.nih.gov/pubmed/33652780 http://dx.doi.org/10.3390/antiox10030349

Ejemplares similares

Polychemotherapy with Curcumin and Doxorubicin via Biological Nanoplatforms: Enhancing Antitumor Activity
por: Ashrafizadeh, Milad, et al.
Publicado: (2020)

Resveratrol Modulates Transforming Growth Factor-Beta (TGF-β) Signaling Pathway for Disease Therapy: A New Insight into Its Pharmacological Activities
por: Ashrafizadeh, Milad, et al.
Publicado: (2020)

Small in Size, but Large in Action: microRNAs as Potential Modulators of PTEN in Breast and Lung Cancers
por: Abadi, Asal Jalal, et al.
Publicado: (2021)

Pre-Clinical and Clinical Applications of Small Interfering RNAs (siRNA) and Co-Delivery Systems for Pancreatic Cancer Therapy
por: Mirzaei, Sepideh, et al.
Publicado: (2021)

Elucidating Role of Reactive Oxygen Species (ROS) in Cisplatin Chemotherapy: A Focus on Molecular Pathways and Possible Therapeutic Strategies
por: Mirzaei, Sepideh, et al.
Publicado: (2021)

Correction: The long and short non-coding RNAs modulating EZH2 signaling in cancer
por: Mirzaei, Sepideh, et al.
Publicado: (2022)

Targeting Cancer Stem Cells by Dietary Agents: An Important Therapeutic Strategy against Human Malignancies
por: Deldar Abad Paskeh, Mahshid, et al.
Publicado: (2021)

Quercetin and Its Nano-Scale Delivery Systems in Prostate Cancer Therapy: Paving the Way for Cancer Elimination and Reversing Chemoresistance
por: Hussain, Yaseen, et al.
Publicado: (2021)

The long and short non-coding RNAs modulating EZH2 signaling in cancer
por: Mirzaei, Sepideh, et al.
Publicado: (2022)

PTEN, a Barrier for Proliferation and Metastasis of Gastric Cancer Cells: From Molecular Pathways to Targeting and Regulation
por: Ashrafizadeh, Milad, et al.
Publicado: (2020)

Emerging role of exosomes in cancer progression and tumor microenvironment remodeling
por: Paskeh, Mahshid Deldar Abad, et al.
Publicado: (2022)

Toward Regulatory Effects of Curcumin on Transforming Growth Factor-Beta Across Different Diseases: A Review
por: Ashrafizadeh, Milad, et al.
Publicado: (2020)

STAT3 Pathway in Gastric Cancer: Signaling, Therapeutic Targeting and Future Prospects
por: Ashrafizadeh, Milad, et al.
Publicado: (2020)

Targeting autophagy in prostate cancer: preclinical and clinical evidence for therapeutic response
por: Ashrafizadeh, Milad, et al.
Publicado: (2022)

Nobiletin in Cancer Therapy: How This Plant Derived-Natural Compound Targets Various Oncogene and Onco-Suppressor Pathways
por: Ashrafizadeh, Milad, et al.
Publicado: (2020)

Chitosan‐based nanoscale systems for doxorubicin delivery: Exploring biomedical application in cancer therapy
por: Ashrafizadeh, Milad, et al.
Publicado: (2022)

Broad-Spectrum Preclinical Antitumor Activity of Chrysin: Current Trends and Future Perspectives
por: Moghadam, Ebrahim Rahmani, et al.
Publicado: (2020)

Association of the Epithelial–Mesenchymal Transition (EMT) with Cisplatin Resistance
por: Ashrafizadeh, Milad, et al.
Publicado: (2020)

Molecular Landscape of LncRNAs in Prostate Cancer: A focus on pathways and therapeutic targets for intervention
por: Mirzaei, Sepideh, et al.
Publicado: (2022)

Progress in Natural Compounds/siRNA Co-delivery Employing Nanovehicles for Cancer Therapy
por: Ashrafizadeh, Milad, et al.
Publicado: (2020)

Role of microRNA/Epithelial-to-Mesenchymal Transition Axis in the Metastasis of Bladder Cancer
por: Ashrafizadeh, Milad, et al.
Publicado: (2020)

MicroRNAs and Their Influence on the ZEB Family: Mechanistic Aspects and Therapeutic Applications in Cancer Therapy
por: Ashrafizadeh, Milad, et al.
Publicado: (2020)

(Nano)platforms in bladder cancer therapy: Challenges and opportunities
por: Ashrafizadeh, Milad, et al.
Publicado: (2022)

Wnt/β-Catenin Signaling as a Driver of Hepatocellular Carcinoma Progression: An Emphasis on Molecular Pathways
por: Deldar Abad Paskeh, Mahshid, et al.
Publicado: (2021)

Chemoprotective and chemosensitizing effects of apigenin on cancer therapy
por: Nozhat, Zahra, et al.
Publicado: (2021)

Flavonoids Targeting HIF-1: Implications on Cancer Metabolism
por: Samec, Marek, et al.
Publicado: (2021)

Exosomes as Promising Nanostructures in Diabetes Mellitus: From Insulin Sensitivity to Ameliorating Diabetic Complications
por: Ashrafizadeh, Milad, et al.
Publicado: (2022)

Progress in Delivery of siRNA-Based Therapeutics Employing Nano-Vehicles for Treatment of Prostate Cancer
por: Ashrafizadeh, Milad, et al.
Publicado: (2020)

Apigenin as Tumor Suppressor in Cancers: Biotherapeutic Activity, Nanodelivery, and Mechanisms With Emphasis on Pancreatic Cancer
por: Ashrafizadeh, Milad, et al.
Publicado: (2020)

A review of medications used to control and improve the signs and symptoms of COVID-19 patients
por: Hushmandi, Kiavash, et al.
Publicado: (2020)

The Diversity of Chemoprotective Glucosinolates in Moringaceae (Moringa spp.)
por: Fahey, Jed W., et al.
Publicado: (2018)

A Systematic Review of the Potential Chemoprotective Effects of Resveratrol on Doxorubicin-Induced Cardiotoxicity: Focus on the Antioxidant, Antiapoptotic, and Anti-Inflammatory Activities
por: Hu, Li-Feng, et al.
Publicado: (2021)

Molecular mechanisms associated with the chemoprotective role of protocatechuic acid and its potential benefits in the amelioration of doxorubicin-induced cardiotoxicity: A review
por: Okpara, Edozie S., et al.
Publicado: (2022)

Potential chemoprotective effects of active ingredients in Salvia miltiorrhiza on doxorubicin-induced cardiotoxicity: a systematic review of in vitro and in vivo studies
por: Wang, Qingqing, et al.
Publicado: (2023)

A Review of Clinical Radioprotection and Chemoprotection for Oral Mucositis
por: Oronsky, Bryan, et al.
Publicado: (2018)

Amygdalin as a chemoprotective agent in co-treatment with cisplatin
por: Christodoulou, Panayiota, et al.
Publicado: (2022)

Chemoprotective potential of Coccinia indica against cyclophosphamide-induced toxicity
por: Nitharwal, Ramesh K, et al.
Publicado: (2013)

Prophylactic efficacy of some chemoprotectants against abrin induced lethality
por: Saxena, Nandita, et al.
Publicado: (2018)

A pharmacokinetic–pharmacodynamic model for chemoprotective agents against malaria
por: Cherkaoui‐Rbati, Mohammed H., et al.
Publicado: (2022)

Targeted delivery of doxorubicin-utilizing chitosan nanoparticles surface-functionalized with anti-Her2 trastuzumab
por: Yousefpour, Parisa, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_q9n0cce3q6ffiveq92uj61o19p