Coupled Feedback Loops Involving PAGE4, EMT and Notch Signaling Can Give Rise to Non-Genetic Heterogeneity in Prostate Cancer Cells

Non-genetic heterogeneity is emerging as a crucial factor underlying therapy resistance in multiple cancers. However, the design principles of regulatory networks underlying non-genetic heterogeneity in cancer remain poorly understood. Here, we investigate the coupled dynamics of feedback loops invo...

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Detalles Bibliográficos
Autores principales: Singh, Divyoj, Bocci, Federico, Kulkarni, Prakash, Jolly, Mohit Kumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7996788/
https://www.ncbi.nlm.nih.gov/pubmed/33652914
http://dx.doi.org/10.3390/e23030288

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7996788/
https://www.ncbi.nlm.nih.gov/pubmed/33652914
http://dx.doi.org/10.3390/e23030288

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