Basigin drives intracellular accumulation of l-lactate by harvesting protons and substrate anions

Transmembrane transport of l-lactate by members of the monocarboxylate transporter family, MCT, is vital in human physiology and a malignancy factor in cancer. Interaction with an accessory protein, typically basigin, is required to deliver the MCT to the plasma membrane. It is unknown whether basig...

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Detalles Bibliográficos
Autores principales: Köpnick, Anna-Lena, Jansen, Annika, Geistlinger, Katharina, Epalle, Nathan Hugo, Beitz, Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7996999/
https://www.ncbi.nlm.nih.gov/pubmed/33770122
http://dx.doi.org/10.1371/journal.pone.0249110

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7996999/
https://www.ncbi.nlm.nih.gov/pubmed/33770122
http://dx.doi.org/10.1371/journal.pone.0249110

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