Short-term treatment of golden retriever muscular dystrophy (GRMD) dogs with rAAVrh74.MHCK7.GALGT2 induces muscle glycosylation and utrophin expression but has no significant effect on muscle strength

We have examined the effects of intravenous (IV) delivery of rAAVrh74.MHCK7.GALGT2 in the golden retriever muscular dystrophy (GRMD) model of Duchenne Muscular Dystrophy (DMD). After baseline testing, GRMD dogs were treated at 3 months of age and reassessed at 6 months. This 3–6 month age range is a...

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Detalles Bibliográficos
Autores principales: Martin, Paul T., Zygmunt, Deborah A., Ashbrook, Anna, Hamilton, Sonia, Packer, Davin, Birch, Sharla M., Bettis, Amanda K., Balog-Alvarez, Cynthia J., Guo, Lee-Jae, Nghiem, Peter P., Kornegay, Joe N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7997012/
https://www.ncbi.nlm.nih.gov/pubmed/33770101
http://dx.doi.org/10.1371/journal.pone.0248721

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7997012/
https://www.ncbi.nlm.nih.gov/pubmed/33770101
http://dx.doi.org/10.1371/journal.pone.0248721

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