Supplemental Ascorbate Diminishes DNA Damage Yet Depletes Glutathione and Increases Acute Liver Failure in a Mouse Model of Hepatic Antioxidant System Disruption

Cellular oxidants are primarily managed by the thioredoxin reductase-1 (TrxR1)- and glutathione reductase (Gsr)-driven antioxidant systems. In mice having hepatocyte-specific co-disruption of TrxR1 and Gsr (TrxR1/Gsr-null livers), methionine catabolism sustains hepatic levels of reduced glutathione...

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Detalles Bibliográficos
Autores principales: Miller, Colin G., Kundert, Jean A., Prigge, Justin R., Amato, Julie A., Perez, Allison E., Coppo, Lucia, Rizzo, Gabrielle N., Kavanaugh, Michael P., Orlicky, David J., Shearn, Colin T., Schmidt, Edward E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7997133/
https://www.ncbi.nlm.nih.gov/pubmed/33673577
http://dx.doi.org/10.3390/antiox10030359

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7997133/
https://www.ncbi.nlm.nih.gov/pubmed/33673577
http://dx.doi.org/10.3390/antiox10030359

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