Oral Proteasomal Inhibitors Ixazomib, Oprozomib, and Delanzomib Upregulate the Function of Organic Anion Transporter 3 (OAT3): Implications in OAT3-Mediated Drug-Drug Interactions

Organic anion transporter 3 (OAT3) is mainly expressed at the basolateral membrane of kidney proximal tubules, and is involved in the renal elimination of various kinds of important drugs, potentially affecting drug efficacy or toxicity. Our laboratory previously reported that ubiquitin modification...

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Detalles Bibliográficos
Autores principales: Fan, Yunzhou, Liang, Zhengxuan, Zhang, Jinghui, You, Guofeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7997269/
https://www.ncbi.nlm.nih.gov/pubmed/33670955
http://dx.doi.org/10.3390/pharmaceutics13030314

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7997269/
https://www.ncbi.nlm.nih.gov/pubmed/33670955
http://dx.doi.org/10.3390/pharmaceutics13030314

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