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Exploring Conformational Dynamics of the Extracellular Venus flytrap Domain of the GABA(B) Receptor: A Path-Metadynamics Study

[Image: see text] γ-Aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the central nervous system (CNS). Dysfunctional GABAergic neurotransmission is associated with numerous neurological and neuropsychiatric disorders. The GABA(B) receptor (GABA(B)-R) is a heterodimeric class C G p...

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Detalles Bibliográficos
Autores principales:	Evenseth, Linn S. M., Ocello, Riccardo, Gabrielsen, Mari, Masetti, Matteo, Recanatini, Maurizio, Sylte, Ingebrigt, Cavalli, Andrea
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2020
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7997371/ https://www.ncbi.nlm.nih.gov/pubmed/32233432 http://dx.doi.org/10.1021/acs.jcim.0c00163

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