Discovery and Optimization of Selective Inhibitors of Meprin α (Part II)

Meprin α is a zinc metalloproteinase (metzincin) that has been implicated in multiple diseases, including fibrosis and cancers. It has proven difficult to find small molecules that are capable of selectively inhibiting meprin α, or its close relative meprin β, over numerous other metzincins which, i...

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Detalles Bibliográficos
Autores principales: Wang, Chao, Diez, Juan, Park, Hajeung, Becker-Pauly, Christoph, Fields, Gregg B., Spicer, Timothy P., Scampavia, Louis D., Minond, Dmitriy, Bannister, Thomas D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7997411/
https://www.ncbi.nlm.nih.gov/pubmed/33673639
http://dx.doi.org/10.3390/ph14030197

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7997411/
https://www.ncbi.nlm.nih.gov/pubmed/33673639
http://dx.doi.org/10.3390/ph14030197

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