Improved Dissolution Rate and Intestinal Absorption of Fexofenadine Hydrochloride by the Preparation of Solid Dispersions: In Vitro and In Situ Evaluation

The objective of this study was to enhance dissolution and permeation of a low soluble, absorbable fexofenadine hydrochloride (FFH) by preparing solid dispersions using polyethylene glycol 20,000 (PEG 20,000) and poloxamer 188 as carriers. The phase solubility measurement for the supplied FFH reveal...

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Detalles Bibliográficos
Autores principales: Eedara, Basanth Babu, Nyavanandi, Dinesh, Narala, Sagar, Veerareddy, Prabhakar Reddy, Bandari, Suresh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7997449/
https://www.ncbi.nlm.nih.gov/pubmed/33673703
http://dx.doi.org/10.3390/pharmaceutics13030310

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7997449/
https://www.ncbi.nlm.nih.gov/pubmed/33673703
http://dx.doi.org/10.3390/pharmaceutics13030310

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