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Improved Dissolution Rate and Intestinal Absorption of Fexofenadine Hydrochloride by the Preparation of Solid Dispersions: In Vitro and In Situ Evaluation

The objective of this study was to enhance dissolution and permeation of a low soluble, absorbable fexofenadine hydrochloride (FFH) by preparing solid dispersions using polyethylene glycol 20,000 (PEG 20,000) and poloxamer 188 as carriers. The phase solubility measurement for the supplied FFH reveal...

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Detalles Bibliográficos
Autores principales:	Eedara, Basanth Babu, Nyavanandi, Dinesh, Narala, Sagar, Veerareddy, Prabhakar Reddy, Bandari, Suresh
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7997449/ https://www.ncbi.nlm.nih.gov/pubmed/33673703 http://dx.doi.org/10.3390/pharmaceutics13030310

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