Lead Optimization of Benzoxazolone Carboxamides as Orally Bioavailable and CNS Penetrant Acid Ceramidase Inhibitors

[Image: see text] Sphingolipids (SphLs) are a diverse class of molecules that are regulated by a complex network of enzymatic pathways. A disturbance in these pathways leads to lipid accumulation and initiation of several SphL-related disorders. Acid ceramidase is one of the key enzymes that regulat...

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Detalles Bibliográficos
Autores principales: Di Martino, Simona, Tardia, Piero, Cilibrasi, Vincenzo, Caputo, Samantha, Mazzonna, Marco, Russo, Debora, Penna, Ilaria, Realini, Natalia, Margaroli, Natasha, Migliore, Marco, Pizzirani, Daniela, Ottonello, Giuliana, Bertozzi, Sine Mandrup, Armirotti, Andrea, Nguyen, Duc, Sun, Ying, Bongarzone, Ernesto R., Lansbury, Peter, Liu, Min, Skerlj, Renato, Scarpelli, Rita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7997574/
https://www.ncbi.nlm.nih.gov/pubmed/32176488
http://dx.doi.org/10.1021/acs.jmedchem.9b02004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7997574/
https://www.ncbi.nlm.nih.gov/pubmed/32176488
http://dx.doi.org/10.1021/acs.jmedchem.9b02004

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