Design, Synthesis, Dynamic Docking, Biochemical Characterization, and in Vivo Pharmacokinetics Studies of Novel Topoisomerase II Poisons with Promising Antiproliferative Activity

[Image: see text] We previously reported a first set of hybrid topoisomerase II (topoII) poisons whose chemical core merges key pharmacophoric elements of etoposide and merbarone, which are two well-known topoII blockers. Here, we report on the expansion of this hybrid molecular scaffold and present...

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Detalles Bibliográficos
Autores principales: Arencibia, Jose M., Brindani, Nicoletta, Franco-Ulloa, Sebastian, Nigro, Michela, Kuriappan, Jissy Akkarapattiakal, Ottonello, Giuliana, Bertozzi, Sine Mandrup, Summa, Maria, Girotto, Stefania, Bertorelli, Rosalia, Armirotti, Andrea, De Vivo, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7997578/
https://www.ncbi.nlm.nih.gov/pubmed/32196342
http://dx.doi.org/10.1021/acs.jmedchem.9b01760

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7997578/
https://www.ncbi.nlm.nih.gov/pubmed/32196342
http://dx.doi.org/10.1021/acs.jmedchem.9b01760

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