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Design, Synthesis, Dynamic Docking, Biochemical Characterization, and in Vivo Pharmacokinetics Studies of Novel Topoisomerase II Poisons with Promising Antiproliferative Activity
[Image: see text] We previously reported a first set of hybrid topoisomerase II (topoII) poisons whose chemical core merges key pharmacophoric elements of etoposide and merbarone, which are two well-known topoII blockers. Here, we report on the expansion of this hybrid molecular scaffold and present...
Autores principales: | Arencibia, Jose M., Brindani, Nicoletta, Franco-Ulloa, Sebastian, Nigro, Michela, Kuriappan, Jissy Akkarapattiakal, Ottonello, Giuliana, Bertozzi, Sine Mandrup, Summa, Maria, Girotto, Stefania, Bertorelli, Rosalia, Armirotti, Andrea, De Vivo, Marco |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical
Society
2020
|
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7997578/ https://www.ncbi.nlm.nih.gov/pubmed/32196342 http://dx.doi.org/10.1021/acs.jmedchem.9b01760 |
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