Applications of genetic-epigenetic tissue mapping for plasma DNA in prenatal testing, transplantation and oncology

We developed genetic-epigenetic tissue mapping (GETMap) to determine the tissue composition of plasma DNA carrying genetic variants not present in the constitutional genome through comparing their methylation profiles with relevant tissues. We validated this approach by showing that, in pregnant wom...

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Detalles Bibliográficos
Autores principales: Gai, Wanxia, Zhou, Ze, Agbor-Enoh, Sean, Fan, Xiaodan, Lian, Sheng, Jiang, Peiyong, Cheng, Suk Hang, Wong, John, Chan, Stephen L, Jang, Moon Kyoo, Yang, Yanqin, Liang, Raymond HS, Chan, Wai Kong, Ma, Edmond SK, Leung, Tak Y, Chiu, Rossa WK, Valantine, Hannah, Chan, KC Allen, Lo, YM Dennis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7997656/
https://www.ncbi.nlm.nih.gov/pubmed/33752803
http://dx.doi.org/10.7554/eLife.64356

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7997656/
https://www.ncbi.nlm.nih.gov/pubmed/33752803
http://dx.doi.org/10.7554/eLife.64356

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