The mTORC1-mediated activation of ATF4 promotes protein and glutathione synthesis downstream of growth signals

The mechanistic target of rapamycin complex 1 (mTORC1) stimulates a coordinated anabolic program in response to growth-promoting signals. Paradoxically, recent studies indicate that mTORC1 can activate the transcription factor ATF4 through mechanisms distinct from its canonical induction by the inte...

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Detalles Bibliográficos
Autores principales: Torrence, Margaret E, MacArthur, Michael R, Hosios, Aaron M, Valvezan, Alexander J, Asara, John M, Mitchell, James R, Manning, Brendan D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7997658/
https://www.ncbi.nlm.nih.gov/pubmed/33646118
http://dx.doi.org/10.7554/eLife.63326

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7997658/
https://www.ncbi.nlm.nih.gov/pubmed/33646118
http://dx.doi.org/10.7554/eLife.63326

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