MED15 prion-like domain forms a coiled-coil responsible for its amyloid conversion and propagation

A disordered to β-sheet transition was thought to drive the functional switch of Q/N-rich prions, similar to pathogenic amyloids. However, recent evidence indicates a critical role for coiled-coil (CC) regions within yeast prion domains in amyloid formation. We show that many human prion-like domain...

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Detalles Bibliográficos
Autores principales: Batlle, Cristina, Calvo, Isabel, Iglesias, Valentin, J. Lynch, Cian, Gil-Garcia, Marcos, Serrano, Manuel, Ventura, Salvador
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7997880/
https://www.ncbi.nlm.nih.gov/pubmed/33772081
http://dx.doi.org/10.1038/s42003-021-01930-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7997880/
https://www.ncbi.nlm.nih.gov/pubmed/33772081
http://dx.doi.org/10.1038/s42003-021-01930-8

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