A conserved role for the ALS-linked splicing factor SFPQ in repression of pathogenic cryptic last exons

The RNA-binding protein SFPQ plays an important role in neuronal development and has been associated with several neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and Alzheimer’s disease. Here, we report that loss of sfpq leads to premature t...

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Detalles Bibliográficos
Autores principales: Gordon, Patricia M., Hamid, Fursham, Makeyev, Eugene V., Houart, Corinne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7997972/
https://www.ncbi.nlm.nih.gov/pubmed/33771997
http://dx.doi.org/10.1038/s41467-021-22098-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7997972/
https://www.ncbi.nlm.nih.gov/pubmed/33771997
http://dx.doi.org/10.1038/s41467-021-22098-z

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