Glutathione ethyl ester reverses the deleterious effects of fentanyl on ventilation and arterial blood-gas chemistry while prolonging fentanyl-induced analgesia

There is an urgent need to develop novel compounds that prevent the deleterious effects of opioids such as fentanyl on minute ventilation while, if possible, preserving the analgesic actions of the opioids. We report that L-glutathione ethyl ester (GSHee) may be such a novel compound. In this study,...

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Detalles Bibliográficos
Autores principales: Jenkins, Michael W., Khalid, Faiza, Baby, Santhosh M., May, Walter J., Young, Alex P., Bates, James N., Cheng, Feixiong, Seckler, James M., Lewis, Stephen J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7997982/
https://www.ncbi.nlm.nih.gov/pubmed/33772077
http://dx.doi.org/10.1038/s41598-021-86458-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7997982/
https://www.ncbi.nlm.nih.gov/pubmed/33772077
http://dx.doi.org/10.1038/s41598-021-86458-x

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