CENP-A overexpression promotes distinct fates in human cells, depending on p53 status

Tumour evolution is driven by both genetic and epigenetic changes. CENP-A, the centromeric histone H3 variant, is an epigenetic mark that directly perturbs genetic stability and chromatin when overexpressed. Although CENP-A overexpression is a common feature of many cancers, how this impacts cell fa...

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Detalles Bibliográficos
Autores principales: Jeffery, Daniel, Gatto, Alberto, Podsypanina, Katrina, Renaud-Pageot, Charlène, Ponce Landete, Rebeca, Bonneville, Lorraine, Dumont, Marie, Fachinetti, Daniele, Almouzni, Geneviève
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7997993/
https://www.ncbi.nlm.nih.gov/pubmed/33772115
http://dx.doi.org/10.1038/s42003-021-01941-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7997993/
https://www.ncbi.nlm.nih.gov/pubmed/33772115
http://dx.doi.org/10.1038/s42003-021-01941-5

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