miR-135a-5p mediates memory and synaptic impairments via the Rock2/Adducin1 signaling pathway in a mouse model of Alzheimer’s disease

Aberrant regulation of microRNAs (miRNAs) has been implicated in the pathogenesis of Alzheimer’s disease (AD), but most abnormally expressed miRNAs found in AD are not regulated by synaptic activity. Here we report that dysfunction of miR-135a-5p/Rock2/Add1 results in memory/synaptic disorder in a m...

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Detalles Bibliográficos
Autores principales: Zheng, Kai, Hu, Fan, Zhou, Yang, Zhang, Juan, Zheng, Jie, Lai, Chuan, Xiong, Wan, Cui, Ke, Hu, Ya-Zhuo, Han, Zhi-Tao, Zhang, Hong-Hong, Chen, Jian-Guo, Man, Heng-Ye, Liu, Dan, Lu, Youming, Zhu, Ling-Qiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7998005/
https://www.ncbi.nlm.nih.gov/pubmed/33771994
http://dx.doi.org/10.1038/s41467-021-22196-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7998005/
https://www.ncbi.nlm.nih.gov/pubmed/33771994
http://dx.doi.org/10.1038/s41467-021-22196-y

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