Vitamin B6 deficiency disrupts serotonin signaling in pancreatic islets and induces gestational diabetes in mice

In pancreatic islets, catabolism of tryptophan into serotonin and serotonin receptor 2B (HTR2B) activation is crucial for β-cell proliferation and maternal glucose regulation during pregnancy. Factors that reduce serotonin synthesis and perturb HTR2B signaling are associated with decreased β-cell nu...

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Detalles Bibliográficos
Autores principales: Fields, Ashley M., Welle, Kevin, Ho, Elaine S., Mesaros, Clementina, Susiarjo, Martha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7998034/
https://www.ncbi.nlm.nih.gov/pubmed/33772108
http://dx.doi.org/10.1038/s42003-021-01900-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7998034/
https://www.ncbi.nlm.nih.gov/pubmed/33772108
http://dx.doi.org/10.1038/s42003-021-01900-0

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