The oncogene AAMDC links PI3K-AKT-mTOR signaling with metabolic reprograming in estrogen receptor-positive breast cancer

Adipogenesis associated Mth938 domain containing (AAMDC) represents an uncharacterized oncogene amplified in aggressive estrogen receptor-positive breast cancers. We uncover that AAMDC regulates the expression of several metabolic enzymes involved in the one-carbon folate and methionine cycles, and...

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Detalles Bibliográficos
Autores principales: Golden, Emily, Rashwan, Rabab, Woodward, Eleanor A., Sgro, Agustin, Wang, Edina, Sorolla, Anabel, Waryah, Charlene, Tie, Wan Jun, Cuyàs, Elisabet, Ratajska, Magdalena, Kardaś, Iwona, Kozlowski, Piotr, Johnstone, Elizabeth K. M., See, Heng B., Duffy, Ciara, Parry, Jeremy, Lagerborg, Kim A., Czapiewski, Piotr, Menendez, Javier A., Gorczyński, Adam, Wasag, Bartosz, Pfleger, Kevin D. G., Curtis, Christina, Lee, Bum-Kyu, Kim, Jonghwan, Cursons, Joseph, Pavlos, Nathan J., Biernat, Wojciech, Jain, Mohit, Woo, Andrew J., Redfern, Andrew, Blancafort, Pilar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7998036/
https://www.ncbi.nlm.nih.gov/pubmed/33772001
http://dx.doi.org/10.1038/s41467-021-22101-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7998036/
https://www.ncbi.nlm.nih.gov/pubmed/33772001
http://dx.doi.org/10.1038/s41467-021-22101-7

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