Dimethyl Fumarate, an Approved Multiple Sclerosis Treatment, Reduces Brain Oxidative Stress in SIV-Infected Rhesus Macaques: Potential Therapeutic Repurposing for HIV Neuroprotection

Dimethyl fumarate (DMF), an antioxidant/anti-inflammatory drug approved for the treatment of multiple sclerosis, induces antioxidant enzymes, in part through transcriptional upregulation. We hypothesized that DMF administration to simian immunodeficiency virus (SIV)-infected rhesus macaques would in...

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Detalles Bibliográficos
Autores principales: Garcia-Mesa, Yoelvis, Xu, He N., Vance, Patricia, Gruenewald, Analise L., Garza, Rolando, Midkiff, Cecily, Alvarez-Hernandez, Xavier, Irwin, David J., Gill, Alexander J., Kolson, Dennis L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7998206/
https://www.ncbi.nlm.nih.gov/pubmed/33803289
http://dx.doi.org/10.3390/antiox10030416

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7998206/
https://www.ncbi.nlm.nih.gov/pubmed/33803289
http://dx.doi.org/10.3390/antiox10030416

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