Accelerating Development of Benziamidazole-Class Proton Pump Inhibitors: A Mechanism-Based PK/PD Model to Optimize Study Design with Ilaprazole as a Case Drug

Proton pump inhibitors (PPIs) are the mainstay for treatment of acid-related diseases. This study developed a mechanism-based pharmacokinetic (PK) and pharmacodynamics (PD) model with ilaprazole as case drug, so as to support and accelerate the development of novel PPIs. The model was established an...

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Detalles Bibliográficos
Autores principales: Jia, Ranran, Zhang, Fan, Wu, Ni, Xu, Wen, Gao, Huitao, Liu, Bo, Wang, Hongyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7998456/
https://www.ncbi.nlm.nih.gov/pubmed/33804279
http://dx.doi.org/10.3390/pharmaceutics13030392

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7998456/
https://www.ncbi.nlm.nih.gov/pubmed/33804279
http://dx.doi.org/10.3390/pharmaceutics13030392

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