Pharmacokinetic Characterization of Supinoxin and Its Physiologically Based Pharmacokinetic Modeling in Rats

Supinoxin is a novel anticancer drug candidate targeting the Y593 phospho-p68 RNA helicase, by exhibiting antiproliferative activity and/or suppression of tumor growth. This study aimed to characterize the in vitro and in vivo pharmacokinetics of supinoxin and attempt physiologically based pharmacok...

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Detalles Bibliográficos
Autores principales: Song, Yoo-Kyung, Seol, Yun-Hwan, Kim, Min Ju, Jeong, Jong-Woo, Choi, Hae-In, Lee, Seung-Won, Chae, Yoon-Jee, Ahn, Sunjoo, Gong, Young-Dae, Lee, Kyeong-Ryoon, Koo, Tae-Sung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7998731/
https://www.ncbi.nlm.nih.gov/pubmed/33799884
http://dx.doi.org/10.3390/pharmaceutics13030373

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7998731/
https://www.ncbi.nlm.nih.gov/pubmed/33799884
http://dx.doi.org/10.3390/pharmaceutics13030373

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