Solubility, Permeability, Anti-Inflammatory Action and In Vivo Pharmacokinetic Properties of Several Mechanochemically Obtained Pharmaceutical Solid Dispersions of Nimesulide

Nimesulide (NIM, N-(4-nitro-2-phenoxyphenyl)methanesulfonamide) is a relatively new nonsteroidal anti-inflammatory analgesic drug. It is practically insoluble in water (<0.02 mg/mL). This very poor aqueous solubility of the drug may lead to low bioavailability. The objective of the present study...

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Detalles Bibliográficos
Autores principales: Wei, Wei, Evseenko, Veronica I., Khvostov, Mikhail V., Borisov, Sergey A., Tolstikova, Tatyana G., Polyakov, Nikolay E., Dushkin, Aleksandr V., Xu, Wenhao, Min, Lu, Su, Weike
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7998760/
https://www.ncbi.nlm.nih.gov/pubmed/33802031
http://dx.doi.org/10.3390/molecules26061513

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7998760/
https://www.ncbi.nlm.nih.gov/pubmed/33802031
http://dx.doi.org/10.3390/molecules26061513

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