Intramolecular Nicholas Reaction Enables the Stereoselective Synthesis of Strained Cyclooctynes

Cyclic products can be obtained through the intramolecular version of the Nicholas reaction, which requires having the nucleophile connected to the alkyne unit. Here, we report the synthesis of 1-oxa-3-cyclooctynes starting from commercially available (1R,3S)-camphoric acid. The strategy is based on...

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Detalles Bibliográficos
Autores principales: Monzón, Diego M., Betancort, Juan Manuel, Martín, Tomás, Ramírez, Miguel Ángel, Martín, Víctor S., Díaz Díaz, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7999112/
https://www.ncbi.nlm.nih.gov/pubmed/33804118
http://dx.doi.org/10.3390/molecules26061629

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7999112/
https://www.ncbi.nlm.nih.gov/pubmed/33804118
http://dx.doi.org/10.3390/molecules26061629

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