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Intramolecular Nicholas Reaction Enables the Stereoselective Synthesis of Strained Cyclooctynes
Cyclic products can be obtained through the intramolecular version of the Nicholas reaction, which requires having the nucleophile connected to the alkyne unit. Here, we report the synthesis of 1-oxa-3-cyclooctynes starting from commercially available (1R,3S)-camphoric acid. The strategy is based on...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7999112/ https://www.ncbi.nlm.nih.gov/pubmed/33804118 http://dx.doi.org/10.3390/molecules26061629 |