Bioluminescence Measurement of Time-Dependent Dynamic Changes of CYP-Mediated Cytotoxicity in CYP-Expressing Luminescent HepG2 Cells

We sought to develop a cell-based cytotoxicity assay using human hepatocytes, which reflect the effects of drug-metabolizing enzymes on cytotoxicity. In this study, we generated luminescent human hepatoblastoma HepG2 cells using the mouse artificial chromosome vector, in which click beetle luciferas...

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Detalles Bibliográficos
Autores principales: Iwado, Satoru, Abe, Satoshi, Oshimura, Mitsuo, Kazuki, Yasuhiro, Nakajima, Yoshihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7999318/
https://www.ncbi.nlm.nih.gov/pubmed/33799598
http://dx.doi.org/10.3390/ijms22062843

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7999318/
https://www.ncbi.nlm.nih.gov/pubmed/33799598
http://dx.doi.org/10.3390/ijms22062843

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