Identification of Decrease in TRiC Proteins as Novel Targets of Alpha-Amanitin-Derived Hepatotoxicity by Comparative Proteomic Analysis In Vitro

Alpha-amanitin (α-AMA) is a cyclic peptide and one of the most lethal mushroom amatoxins found in Amanita phalloides. α-AMA is known to cause hepatotoxicity through RNA polymerase II inhibition, which acts in RNA and DNA translocation. To investigate the toxic signature of α-AMA beyond known mechani...

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Detalles Bibliográficos
Autores principales: Kim, Doeun, Kim, Sunjoo, Na, Ann-Yae, Sohn, Chang Hwan, Lee, Sangkyu, Lee, Hye Suk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7999322/
https://www.ncbi.nlm.nih.gov/pubmed/33803263
http://dx.doi.org/10.3390/toxins13030197

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7999322/
https://www.ncbi.nlm.nih.gov/pubmed/33803263
http://dx.doi.org/10.3390/toxins13030197

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