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Relationship between Thyroid Status during the First Trimester of Pregnancy and Neonatal Well-Being

Iodine is an essential micronutrient for the synthesis of thyroid hormones. The proper functioning of the thyroid axis is essential for the normal development of the nervous system, especially in the first trimester of gestation. The aim of the present study was to analyze the perinatal outcomes, an...

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Autores principales: Murillo-Llorente, Maria Teresa, Llorca-Colomer, Francisco, Pérez-Bermejo, Marcelino
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7999325/
https://www.ncbi.nlm.nih.gov/pubmed/33799943
http://dx.doi.org/10.3390/nu13030872
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author Murillo-Llorente, Maria Teresa
Llorca-Colomer, Francisco
Pérez-Bermejo, Marcelino
author_facet Murillo-Llorente, Maria Teresa
Llorca-Colomer, Francisco
Pérez-Bermejo, Marcelino
author_sort Murillo-Llorente, Maria Teresa
collection PubMed
description Iodine is an essential micronutrient for the synthesis of thyroid hormones. The proper functioning of the thyroid axis is essential for the normal development of the nervous system, especially in the first trimester of gestation. The aim of the present study was to analyze the perinatal outcomes, anthropometry, and APGAR test scores of newborns and to relate them to maternal thyroid status. A total of 190 newborns participated in the study. No correlation was found between thyroid stimulating hormone (TSH) and maternal ioduria values in the first trimester of gestation with the weight or length of the newborn, or the APGAR score at one minute after birth. However, we found significant differences between the APGAR scores of children whose mothers had an iodine sufficiency level in the first trimester compared to the children of mothers with iodine deficiency. Similarly, the APGAR scores of children whose mothers had a TSH > 4 have significantly better APGAR scores than the children of mothers with a TSH < 4. Likewise, we found significant differences between the measurements of the newborns depending on whether their mothers smoked. The children of mothers who took iodine supplements or iodized salt obtained the highest APGAR score at one and five minutes after birth. It is essential to focus on recommending adequate consumption of iodine supplements and iodized salt prior to gestation and at least during the first trimester to achieve better fetal well-being.
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spelling pubmed-79993252021-03-28 Relationship between Thyroid Status during the First Trimester of Pregnancy and Neonatal Well-Being Murillo-Llorente, Maria Teresa Llorca-Colomer, Francisco Pérez-Bermejo, Marcelino Nutrients Article Iodine is an essential micronutrient for the synthesis of thyroid hormones. The proper functioning of the thyroid axis is essential for the normal development of the nervous system, especially in the first trimester of gestation. The aim of the present study was to analyze the perinatal outcomes, anthropometry, and APGAR test scores of newborns and to relate them to maternal thyroid status. A total of 190 newborns participated in the study. No correlation was found between thyroid stimulating hormone (TSH) and maternal ioduria values in the first trimester of gestation with the weight or length of the newborn, or the APGAR score at one minute after birth. However, we found significant differences between the APGAR scores of children whose mothers had an iodine sufficiency level in the first trimester compared to the children of mothers with iodine deficiency. Similarly, the APGAR scores of children whose mothers had a TSH > 4 have significantly better APGAR scores than the children of mothers with a TSH < 4. Likewise, we found significant differences between the measurements of the newborns depending on whether their mothers smoked. The children of mothers who took iodine supplements or iodized salt obtained the highest APGAR score at one and five minutes after birth. It is essential to focus on recommending adequate consumption of iodine supplements and iodized salt prior to gestation and at least during the first trimester to achieve better fetal well-being. MDPI 2021-03-07 /pmc/articles/PMC7999325/ /pubmed/33799943 http://dx.doi.org/10.3390/nu13030872 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Article
Murillo-Llorente, Maria Teresa
Llorca-Colomer, Francisco
Pérez-Bermejo, Marcelino
Relationship between Thyroid Status during the First Trimester of Pregnancy and Neonatal Well-Being
title Relationship between Thyroid Status during the First Trimester of Pregnancy and Neonatal Well-Being
title_full Relationship between Thyroid Status during the First Trimester of Pregnancy and Neonatal Well-Being
title_fullStr Relationship between Thyroid Status during the First Trimester of Pregnancy and Neonatal Well-Being
title_full_unstemmed Relationship between Thyroid Status during the First Trimester of Pregnancy and Neonatal Well-Being
title_short Relationship between Thyroid Status during the First Trimester of Pregnancy and Neonatal Well-Being
title_sort relationship between thyroid status during the first trimester of pregnancy and neonatal well-being
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7999325/
https://www.ncbi.nlm.nih.gov/pubmed/33799943
http://dx.doi.org/10.3390/nu13030872
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