Cargando…

Simultaneous CD8(+) T-Cell Immune Response against SARS-Cov-2 S, M, and N Induced by Endogenously Engineered Extracellular Vesicles in Both Spleen and Lungs

Most advanced vaccines against severe acute respiratory syndrome coronavirus (SARS-CoV)-2 are designed to induce antibodies against spike (S) protein. Differently, we developed an original strategy to induce CD8(+) T cytotoxic lymphocyte (CTL) immunity based on in vivo engineering of extracellular v...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ferrantelli, Flavia, Chiozzini, Chiara, Manfredi, Francesco, Giovannelli, Andrea, Leone, Patrizia, Federico, Maurizio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7999804/ https://www.ncbi.nlm.nih.gov/pubmed/33801926 http://dx.doi.org/10.3390/vaccines9030240

Ejemplares similares

Long-Term Antitumor CD8(+) T Cell Immunity Induced by Endogenously Engineered Extracellular Vesicles
por: Ferrantelli, Flavia, et al.
Publicado: (2021)

The C-Terminal Domain of Nef(mut) Is Dispensable for the CD8(+) T Cell Immunogenicity of In Vivo Engineered Extracellular Vesicles
por: Chiozzini, Chiara, et al.
Publicado: (2021)

Activation of Anti-SARS-CoV-2 Human CTLs by Extracellular Vesicles Engineered with the N Viral Protein
por: Manfredi, Francesco, et al.
Publicado: (2022)

Engineered Extracellular Vesicles/Exosomes as a New Tool against Neurodegenerative Diseases
por: Ferrantelli, Flavia, et al.
Publicado: (2020)

N-Terminal Fatty Acids of NEF(MUT) Are Required for the CD8(+) T-Cell Immunogenicity of In Vivo Engineered Extracellular Vesicles
por: Chiozzini, Chiara, et al.
Publicado: (2020)

Strong SARS-CoV-2 N-Specific CD8(+) T Immunity Induced by Engineered Extracellular Vesicles Associates with Protection from Lethal Infection in Mice
por: Ferrantelli, Flavia, et al.
Publicado: (2022)

Antiviral effect of SARS-CoV-2 N-specific CD8(+) T cells induced in lungs by engineered extracellular vesicles
por: Manfredi, Francesco, et al.
Publicado: (2023)

The Intracellular Delivery Of Anti-HPV16 E7 scFvs Through Engineered Extracellular Vesicles Inhibits The Proliferation Of HPV-Infected Cells
por: Ferrantelli, Flavia, et al.
Publicado: (2019)

SARS-CoV-2-Specific CD8(+) T-Cells in Blood but Not in the Lungs of Vaccinated K18-hACE2 Mice after Infection
por: Ferrantelli, Flavia, et al.
Publicado: (2023)

Exploiting Manipulated Small Extracellular Vesicles to Subvert Immunosuppression at the Tumor Microenvironment through Mannose Receptor/CD206 Targeting
por: Fiani, Maria Luisa, et al.
Publicado: (2020)

Antitumor HPV E7-specific CTL activity elicited by in vivo engineered exosomes produced through DNA inoculation
por: Di Bonito, Paola, et al.
Publicado: (2017)

HPV-E7 Delivered by Engineered Exosomes Elicits a Protective CD8(+) T Cell-Mediated Immune Response
por: Di Bonito, Paola, et al.
Publicado: (2015)

Anti-Cancer Vaccine for HPV-Associated Neoplasms: Focus on a Therapeutic HPV Vaccine Based on a Novel Tumor Antigen Delivery Method Using Endogenously Engineered Exosomes
por: Di Bonito, Paola, et al.
Publicado: (2019)

The CD8(+) T Cell-Mediated Immunity Induced by HPV-E6 Uploaded in Engineered Exosomes Is Improved by ISCOMATRIX(TM) Adjuvant
por: Manfredi, Francesco, et al.
Publicado: (2016)

Identification of scaffold proteins for improved endogenous engineering of extracellular vesicles
por: Zheng, Wenyi, et al.
Publicado: (2023)

Cell activation and HIV-1 replication in unstimulated CD4(+) T lymphocytes ingesting exosomes from cells expressing defective HIV-1
por: Arenaccio, Claudia, et al.
Publicado: (2014)

Latent HIV-1 is activated by exosomes from cells infected with either replication-competent or defective HIV-1
por: Arenaccio, Claudia, et al.
Publicado: (2015)

Strategies for Engineering of Extracellular Vesicles
por: Danilushkina, Anna A., et al.
Publicado: (2023)

Therapeutic Potential of Engineered Extracellular Vesicles
por: Mentkowski, Kyle I., et al.
Publicado: (2018)

Emerging technologies for engineering of extracellular vesicles
por: Zhou, Xin, et al.
Publicado: (2023)

Extracellular Vesicles Mediate Radiation-Induced Systemic Bystander Signals in the Bone Marrow and Spleen
por: Szatmári, Tünde, et al.
Publicado: (2017)

In Vivo Characterization of Endogenous Cardiovascular Extracellular Vesicles in Larval and Adult Zebrafish
por: Scott, Aaron, et al.
Publicado: (2021)

Extracellular Vesicle Characteristics in β-thalassemia as Potential Biomarkers for Spleen Functional Status and Ineffective Erythropoiesis
por: Levin, Carina, et al.
Publicado: (2018)

Engineering Extracellular Vesicles as Nanotherapeutics for Regenerative Medicine
por: Ramasubramanian, Lalithasri, et al.
Publicado: (2019)

Native and engineered extracellular vesicles for wound healing
por: Lu, Shengli, et al.
Publicado: (2022)

Surface-Engineered Extracellular Vesicles in Cancer Immunotherapy
por: Johnson, Vinith, et al.
Publicado: (2023)

Editorial: Engineered extracellular vesicles for tissue repairing
por: Yu, Shiyi, et al.
Publicado: (2023)

Engineered extracellular vesicles for ischemic stroke treatment
por: Ruan, Huitong, et al.
Publicado: (2023)

Extracellular vesicle Cystatin C and CD14 are associated with both renal dysfunction and heart failure
por: Verbree‐Willemsen, Laura, et al.
Publicado: (2020)

Improved isolation of extracellular vesicles by removal of both free proteins and lipoproteins
por: Ter-Ovanesyan, Dmitry, et al.
Publicado: (2023)

Triggering Endogenous Cardiac Repair and Regeneration via Extracellular Vesicle-Mediated Communication
por: Bollini, Sveva, et al.
Publicado: (2018)

Extracellular Vesicles: New Endogenous Shuttles for miRNAs in Cancer Diagnosis and Therapy?
por: Martellucci, Stefano, et al.
Publicado: (2020)

Charge-based precipitation of extracellular vesicles
por: Deregibus, Maria Chiara, et al.
Publicado: (2016)

Engineering Extracellular Vesicles with the Tools of Enzyme Prodrug Therapy
por: Fuhrmann, Gregor, et al.
Publicado: (2018)

Engineering Extracellular Vesicles to Target Pancreatic Tissue In Vivo
por: Komuro, Hiroaki, et al.
Publicado: (2021)

Application of engineered extracellular vesicles for targeted tumor therapy
por: Zhang, Fusheng, et al.
Publicado: (2022)

Engineered extracellular vesicles: potentials in cancer combination therapy
por: Chen, Jiangbin, et al.
Publicado: (2022)

Internalisation of RGD-Engineered Extracellular Vesicles by Glioblastoma Cells
por: Gečys, Dovydas, et al.
Publicado: (2022)

Advances of engineered extracellular vesicles-based therapeutics strategy
por: Komuro, Hiroaki, et al.
Publicado: (2022)

Engineering Extracellular Vesicles as Delivery Systems in Therapeutic Applications
por: Wang, Liwei, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_ol67e5l7rped5159kfc5efepei