Mechanism of misfolding of the human prion protein revealed by a pathological mutation

The misfolding and aggregation of the human prion protein (PrP) is associated with transmissible spongiform encephalopathies (TSEs). Intermediate conformations forming during the conversion of the cellular form of PrP into its pathological scrapie conformation are key drivers of the misfolding proce...

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Detalles Bibliográficos
Autores principales: Sanz-Hernández, Máximo, Barritt, Joseph D., Sobek, Jens, Hornemann, Simone, Aguzzi, Adriano, De Simone, Alfonso
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7999870/
https://www.ncbi.nlm.nih.gov/pubmed/33731477
http://dx.doi.org/10.1073/pnas.2019631118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7999870/
https://www.ncbi.nlm.nih.gov/pubmed/33731477
http://dx.doi.org/10.1073/pnas.2019631118

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