Combined Inactivation of Pocket Proteins and APC/C(Cdh1) by Cdk4/6 Controls Recovery from DNA Damage in G1 Phase

Most Cyclin-dependent kinases (Cdks) are redundant for normal cell division. Here we tested whether these redundancies are maintained during cell cycle recovery after a DNA damage-induced arrest in G1. Using non-transformed RPE-1 cells, we find that while Cdk4 and Cdk6 act redundantly during normal...

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Detalles Bibliográficos
Autores principales: Shaltiel, Indra A., Llopis, Alba, Aprelia, Melinda, Klompmaker, Rob, Menegakis, Apostolos, Krenning, Lenno, Medema, René H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7999910/
https://www.ncbi.nlm.nih.gov/pubmed/33806417
http://dx.doi.org/10.3390/cells10030550

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7999910/
https://www.ncbi.nlm.nih.gov/pubmed/33806417
http://dx.doi.org/10.3390/cells10030550

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