Cargando…

Combined Inactivation of Pocket Proteins and APC/C(Cdh1) by Cdk4/6 Controls Recovery from DNA Damage in G1 Phase

Most Cyclin-dependent kinases (Cdks) are redundant for normal cell division. Here we tested whether these redundancies are maintained during cell cycle recovery after a DNA damage-induced arrest in G1. Using non-transformed RPE-1 cells, we find that while Cdk4 and Cdk6 act redundantly during normal...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shaltiel, Indra A., Llopis, Alba, Aprelia, Melinda, Klompmaker, Rob, Menegakis, Apostolos, Krenning, Lenno, Medema, René H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7999910/ https://www.ncbi.nlm.nih.gov/pubmed/33806417 http://dx.doi.org/10.3390/cells10030550

Ejemplares similares

Resistance of Hypoxic Cells to Ionizing Radiation Is Mediated in Part via Hypoxia-Induced Quiescence
por: Menegakis, Apostolos, et al.
Publicado: (2021)

An APC/C-Cdh1 Biosensor Reveals the Dynamics of Cdh1 Inactivation at the G1/S Transition
por: Ondracka, Andrej, et al.
Publicado: (2016)

Structures of APC/C(Cdh1) with substrates identify Cdh1 and Apc10 as the D-box co-receptor
por: da Fonseca, Paula C.A., et al.
Publicado: (2010)

New origin firing is inhibited by APC/C(Cdh1) activation in S-phase after severe replication stress
por: Ercilla, Amaia, et al.
Publicado: (2016)

Dual control by Cdk1 phosphorylation of the budding yeast APC/C ubiquitin ligase activator Cdh1
por: Höckner, Sebastian, et al.
Publicado: (2016)

Polo-Like Kinase-1 Controls Aurora A Destruction by Activating APC/C-Cdh1
por: van Leuken, Renske, et al.
Publicado: (2009)

Sustained CHK2 activity, but not ATM activity, is critical to maintain a G1 arrest after DNA damage in untransformed cells
por: García-Santisteban, Iraia, et al.
Publicado: (2021)

γ-Tubulin plays a key role in inactivating APC/C(Cdh1) at the G(1)–S boundary
por: Edgerton-Morgan, Heather, et al.
Publicado: (2012)

The spindle checkpoint, APC/C(Cdc20), and APC/C(Cdh1) play distinct roles in connecting mitosis to S phase
por: Clijsters, Linda, et al.
Publicado: (2013)

The function of APC/C(Cdh1 )in cell cycle and beyond
por: Li, Min, et al.
Publicado: (2009)

Controlling the response to DNA damage by the APC/C-Cdh1
por: de Boer, H. Rudolf, et al.
Publicado: (2015)

Damaged DNA-binding Protein 1 (DDB1) Interacts with Cdh1 and Modulates the Function of APC/C(Cdh1)
por: Lv, Xiao-Bin, et al.
Publicado: (2010)

Expression of Constitutively Active CDK1 Stabilizes APC-Cdh1 Substrates and Potentiates Premature Spindle Assembly and Checkpoint Function in G1 Cells
por: Ma, Yan, et al.
Publicado: (2012)

Low CDK Activity and Enhanced Degradation by APC/C(CDH1) Abolishes CtIP Activity and Alt-EJ in Quiescent Cells
por: Li, Fanghua, et al.
Publicado: (2023)

Cdk5-mediated inhibition of APC/C-Cdh1 switches on the cyclin D1-Cdk4-pRb pathway causing aberrant S-phase entry of postmitotic neurons
por: Veas-Pérez de Tudela, Miguel, et al.
Publicado: (2015)

Uncovering the role of APC-Cdh1 in generating the dynamics of S-phase onset
por: Yuan, Xi, et al.
Publicado: (2014)

Regulation of APC/C-Cdh1 and Its Function in Neuronal Survival
por: Almeida, Angeles
Publicado: (2012)

Erratum to: Controlling the response to DNA damage by the APC/C-Cdh1
por: de Boer, H. Rudolf, et al.
Publicado: (2016)

The APC/C recruits cyclin B1–Cdk1–Cks in prometaphase before D box recognition to control mitotic exit
por: van Zon, Wouter, et al.
Publicado: (2010)

Spatial Separation of Plk1 Phosphorylation and Activity
por: Bruinsma, Wytse, et al.
Publicado: (2015)

APC/C-Cdh1-targeted substrates as potential therapies for Alzheimer’s disease
por: Lapresa, Rebeca, et al.
Publicado: (2022)

Disjunction of conjoined twins: Cdk1, Cdh1 and separation of centrosomes
por: Crasta, Karen, et al.
Publicado: (2006)

Regulation of mitochondrial morphology by APC/C(Cdh1)-mediated control of Drp1 stability
por: Horn, Sarah R., et al.
Publicado: (2011)

A Cdh1–FoxM1–Apc axis controls muscle development and regeneration
por: Chen, Zhe, et al.
Publicado: (2020)

Cyclin E overexpression impairs progression through mitosis by inhibiting APC(Cdh1)
por: Keck, Jamie M., et al.
Publicado: (2007)

APC/C-Cdh1-dependent anaphase and telophase progression during mitotic slippage
por: Toda, Kazuhiro, et al.
Publicado: (2012)

APC(CDH1) Targets MgcRacGAP for Destruction in the Late M Phase
por: Nishimura, Koutarou, et al.
Publicado: (2013)

The ubiquitin ligase APC/C(Cdh1) puts the brakes on DNA-end resection
por: Lafranchi, Lorenzo, et al.
Publicado: (2015)

Insights into Degron Recognition by APC/C Coactivators from the Structure of an Acm1-Cdh1 Complex
por: He, Jun, et al.
Publicado: (2013)

Chromosomes trapped in micronuclei are liable to segregation errors
por: Soto, Mar, et al.
Publicado: (2018)

APC(cdh1) Mediates Degradation of the Oncogenic Rho-GEF Ect2 after Mitosis
por: Liot, Caroline, et al.
Publicado: (2011)

Correction: APC(CDH1) Targets MgcRacGAP for Destruction in the Late M Phase
Publicado: (2014)

Targeting of Fzr/Cdh1 for timely activation of the APC/C at the centrosome during mitotic exit
por: Meghini, Francesco, et al.
Publicado: (2016)

The Role of the APC/C and Its Coactivators Cdh1 and Cdc20 in Cancer Development and Therapy
por: Greil, Christine, et al.
Publicado: (2022)

APC/C(Cdh1)-dependent proteolysis of USP1 regulates the response to UV-mediated DNA damage
por: Cotto-Rios, Xiomaris M., et al.
Publicado: (2011)

Human KIAA1018/FAN1 nuclease is a new mitotic substrate of APC/C(Cdh1)
por: Lai, Fenju, et al.
Publicado: (2012)

Substrate binding on the APC/C occurs between the co-activator CDH1 and the processivity factor DOC1
por: Buschhorn, Bettina A., et al.
Publicado: (2010)

Phosphorylation of MCPH1 isoforms during mitosis followed by isoform-specific degradation by APC/C-CDH1
por: Meyer, Stephanie K., et al.
Publicado: (2019)

Time-resolved single-cell sequencing identifies multiple waves of mRNA decay during the mitosis-to-G1 phase transition
por: Krenning, Lenno, et al.
Publicado: (2022)

Direct interaction between Smad3, APC10, CDH1 and HEF1 in proteasomal degradation of HEF1
por: Nourry, Claire, et al.
Publicado: (2004)

Cannot write session to /tmp/vufind_sessions/sess_ongl2n85qvtn6bsc50cdr2tifj