Activation of a Cryptic Manumycin-Type Biosynthetic Gene Cluster of Saccharothrix espanaensis DSM44229 by Series of Genetic Manipulations

(1) Background: Manumycins are small actinomycete polyketides with prominent cancerostatic and immunosuppressive activities via inhibition of various eukaryotic enzymes. Their overall activity towards human cells depends on the structural variability of both their polyketide chains, mainly the upper...

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Detalles Bibliográficos
Autores principales: Gorniaková, Dominika, Petříček, Miroslav, Kahoun, David, Grabic, Roman, Zelenka, Tomáš, Chroňáková, Alica, Petříčková, Kateřina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8000086/
https://www.ncbi.nlm.nih.gov/pubmed/33800500
http://dx.doi.org/10.3390/microorganisms9030559

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8000086/
https://www.ncbi.nlm.nih.gov/pubmed/33800500
http://dx.doi.org/10.3390/microorganisms9030559

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