Protein design-scapes generated by microfluidic DNA assembly elucidate domain coupling in the bacterial histidine kinase CpxA

The randomization and screening of combinatorial DNA libraries is a powerful technique for understanding sequence–function relationships and optimizing biosynthetic pathways. Although it can be difficult to predict a priori which sequence combinations encode functional units, it is often possible to...

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Detalles Bibliográficos
Autores principales: Clark, Iain C., Mensa, Bruk, Ochs, Christopher J., Schmidt, Nathan W., Mravic, Marco, Quintana, Francisco J., DeGrado, William F., Abate, Adam R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8000134/
https://www.ncbi.nlm.nih.gov/pubmed/33723045
http://dx.doi.org/10.1073/pnas.2017719118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8000134/
https://www.ncbi.nlm.nih.gov/pubmed/33723045
http://dx.doi.org/10.1073/pnas.2017719118

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