Screening of 5- and 6-Substituted Amiloride Libraries Identifies Dual-uPA/NHE1 Active and Single Target-Selective Inhibitors

The K(+)-sparing diuretic amiloride shows off-target anti-cancer effects in multiple rodent models. These effects arise from the inhibition of two distinct cancer targets: the trypsin-like serine protease urokinase-type plasminogen activator (uPA), a cell-surface mediator of matrix degradation and t...

Descripción completa

Detalles Bibliográficos
Autores principales: Buckley, Benjamin J., Kumar, Ashna, Aboelela, Ashraf, Bujaroski, Richard S., Li, Xiuju, Majed, Hiwa, Fliegel, Larry, Ranson, Marie, Kelso, Michael J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8000185/
https://www.ncbi.nlm.nih.gov/pubmed/33804289
http://dx.doi.org/10.3390/ijms22062999

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8000185/
https://www.ncbi.nlm.nih.gov/pubmed/33804289
http://dx.doi.org/10.3390/ijms22062999

Ejemplares similares