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Multi-scale Predictions of Drug Resistance Epidemiology Identify Design Principles for Rational Drug Design
Rationally designing drugs that last longer in the face of biological evolution is a critical objective of drug discovery. However, this goal is thwarted by the diversity and stochasticity of evolutionary trajectories that drive uncertainty in the clinic. Although biophysical models can qualitativel...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8000225/ https://www.ncbi.nlm.nih.gov/pubmed/32209458 http://dx.doi.org/10.1016/j.celrep.2020.02.108 |