The Effect of Small Molecule Pharmacological Agents on the Triterpenoid Saponin Induced Endolysosomal Escape of Saporin and a Saporin-Based Immunotoxin in Target Human Lymphoma Cells

Triterpenoid saponins augment the cytotoxicity of saporin based immunotoxins. It is postulated that this results from a saponin-mediated increase in the endolysosomal escape of the toxin to the cytosol, but this remains to be confirmed. To address this issue, we used a number of pharmacological inhi...

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Detalles Bibliográficos
Autores principales: Wensley, Harrison J., Smith, Wendy S., Holmes, Suzanne E., Flavell, Sopsamorn U., Flavell, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8000476/
https://www.ncbi.nlm.nih.gov/pubmed/33804080
http://dx.doi.org/10.3390/biomedicines9030300

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8000476/
https://www.ncbi.nlm.nih.gov/pubmed/33804080
http://dx.doi.org/10.3390/biomedicines9030300

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