Paradoxical androgen receptor regulation by small molecule enantiomers

Small molecules that target the androgen receptor (AR) are the mainstay of therapy for lethal castration-resistant prostate cancer (CRPC), yet existing drugs lose their efficacy during continued treatment. This evolution of resistance is due to heterogenous mechanisms which include AR mutations caus...

Descripción completa

Detalles Bibliográficos
Autores principales: Patsch, Katherin, Liu, Chao, Zapotoczny, Grzegorz, Sun, Yuanye, Sura, Harish, Ung, Nolan, Sun, Ren X., Haliday, Bethany, Yu, Chen, Aljehani, Mayada, Lee, Jerry S. H., Kashemirov, Boris A., Agus, David B., McKenna, Charles E., Ruderman, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8000581/
https://www.ncbi.nlm.nih.gov/pubmed/33741738
http://dx.doi.org/10.1073/pnas.2100918118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8000581/
https://www.ncbi.nlm.nih.gov/pubmed/33741738
http://dx.doi.org/10.1073/pnas.2100918118

Ejemplares similares