Cargando…
Trans-Epithelial Transport, Metabolism, and Biological Activity Assessment of the Multi-Target Lupin Peptide LILPKHSDAD (P5) and Its Metabolite LPKHSDAD (P5-Met)
P5 (LILPKHSDAD) is a hypocholesterolemic peptide from lupin protein with a multi-target activity, since it inhibits both 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCoAR) and proprotein convertase subtilisin/kexin type-9 (PCSK9). This work shows that, during epithelial transport experiments,...
Autores principales: | Lammi, Carmen, Aiello, Gilda, Bollati, Carlotta, Li, Jianqiang, Bartolomei, Martina, Ranaldi, Giulia, Ferruzza, Simonetta, Fassi, Enrico Mario Alessandro, Grazioso, Giovanni, Sambuy, Yula, Arnoldi, Anna |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8000724/ https://www.ncbi.nlm.nih.gov/pubmed/33808034 http://dx.doi.org/10.3390/nu13030863 |
Ejemplares similares
-
Assessment of the Multifunctional Behavior of Lupin Peptide P7 and
Its Metabolite Using an Integrated Strategy
por: Lammi, Carmen, et al.
Publicado: (2020) -
Soybean- and Lupin-Derived Peptides Inhibit DPP-IV Activity on In Situ Human Intestinal Caco-2 Cells and Ex Vivo Human Serum
por: Lammi, Carmen, et al.
Publicado: (2018) -
Hypocholesterolaemic Activity of Lupin Peptides: Investigation on the Crosstalk between Human Enterocytes and Hepatocytes Using a Co-Culture System Including Caco-2 and HepG2 Cells
por: Lammi, Carmen, et al.
Publicado: (2016) -
Extra Virgin Olive Oil Phenolic Extract on Human Hepatic HepG2 and Intestinal Caco-2 Cells: Assessment of the Antioxidant Activity and Intestinal Trans-Epithelial Transport
por: Bartolomei, Martina, et al.
Publicado: (2021) -
Computational Design and Biological Evaluation of Analogs of Lupin Peptide P5 Endowed with Dual PCSK9/HMG-CoAR Inhibiting Activity
por: Lammi, Carmen, et al.
Publicado: (2022)