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Probing the Structure and Function of the Cytosolic Domain of the Human Zinc Transporter ZnT8 with Nickel(II) Ions

The human zinc transporter ZnT8 provides the granules of pancreatic β-cells with zinc (II) ions for assembly of insulin hexamers for storage. Until recently, the structure and function of human ZnTs have been modelled on the basis of the 3D structures of bacterial zinc exporters, which form homodime...

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Detalles Bibliográficos
Autores principales: Catapano, Maria Carmen, Parsons, Douglas S., Kotuniak, Radosław, Mladěnka, Přemysl, Bal, Wojciech, Maret, Wolfgang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8000985/
https://www.ncbi.nlm.nih.gov/pubmed/33799326
http://dx.doi.org/10.3390/ijms22062940