Mucoadhesive In Situ Rectal Gel Loaded with Rifampicin: Strategy to Improve Bioavailability and Alleviate Liver Toxicity

Although it is a front-line in tuberculosis treatment, rifampicin (RF) exhibits poor oral bioavailability and hepatotoxicity. Rectal mucoadhesive and in situ rectal gels were developed to overcome drug drawbacks. A RF/polyethylene glycol 6000 co-precipitate was first prepared in different ratios. Ba...

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Detalles Bibliográficos
Autores principales: Al-Joufi, Fakhria, Elmowafy, Mohammed, Alruwaili, Nabil K., Alharbi, Khalid S., Shalaby, Khaled, Alsharari, Shakir D., Ali, Hazim M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8001001/
https://www.ncbi.nlm.nih.gov/pubmed/33807729
http://dx.doi.org/10.3390/pharmaceutics13030336

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8001001/
https://www.ncbi.nlm.nih.gov/pubmed/33807729
http://dx.doi.org/10.3390/pharmaceutics13030336

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