Biflavonoid-Induced Disruption of Hydrogen Bonds Leads to Amyloid-β Disaggregation

Deposition of amyloid β (Aβ) fibrils in the brain is a key pathologic hallmark of Alzheimer’s disease. A class of polyphenolic biflavonoids is known to have anti-amyloidogenic effects by inhibiting aggregation of Aβ and promoting disaggregation of Aβ fibrils. In the present study, we further sought...

Descripción completa

Detalles Bibliográficos
Autores principales: Windsor, Peter K., Plassmeyer, Stephen P., Mattock, Dominic S., Bradfield, Jonathan C., Choi, Erika Y., Miller, Bill R., Han, Byung Hee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8001082/
https://www.ncbi.nlm.nih.gov/pubmed/33809196
http://dx.doi.org/10.3390/ijms22062888

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8001082/
https://www.ncbi.nlm.nih.gov/pubmed/33809196
http://dx.doi.org/10.3390/ijms22062888

Ejemplares similares