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Biflavonoid-Induced Disruption of Hydrogen Bonds Leads to Amyloid-β Disaggregation
Deposition of amyloid β (Aβ) fibrils in the brain is a key pathologic hallmark of Alzheimer’s disease. A class of polyphenolic biflavonoids is known to have anti-amyloidogenic effects by inhibiting aggregation of Aβ and promoting disaggregation of Aβ fibrils. In the present study, we further sought...
Autores principales: | Windsor, Peter K., Plassmeyer, Stephen P., Mattock, Dominic S., Bradfield, Jonathan C., Choi, Erika Y., Miller, Bill R., Han, Byung Hee |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8001082/ https://www.ncbi.nlm.nih.gov/pubmed/33809196 http://dx.doi.org/10.3390/ijms22062888 |
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